Endosalpingiosis is a rare gynecological condition, which can affect females in reproductive age and postmenopausal women.  Abdominal pain is a commonly reported symptom of Endosalpingiosis. Characterized by the presence of tubal epithelium outside the fallopian tube, it can affect any organ in the abdomen and pelvis. High associations of Endosalpingiosis are found with ovarian cancer, endometriosis, and uterine cancer.


What is Endosalpingiosis?

Endosalpingiosis is the abnormal presence of endometrial glands and stroma in areas outside of the uterine. This rare condition mostly occurs in the pelvis but can be found throughout different body sites. Urinary tract endometriosis refers to the presence of this condition in the urethra, bladder, ureters or kidneys. Mullerianosis is a term that describes the presence of the endocervix, endosalpinx and/or endometrial tissues growing in the wrong location of the pelvic area.

For those that want a little more clinical detail ...

This rare condition is characterized by the presence of ectopic, cystic glands lined with ciliated epithelium similar to that found in the fallopian tube. It is most commonly found on pelvic organs such as the uterine serosa, fallopian tube serosa, ovaries, round ligament, and bladder, but has been documented in many other abdominal peritoneal and subperitoneal surfaces, including in retroperitoneal lymph nodes. It was first described by Sampson in 1930 when epithelium resembling the fallopian tube was noted in the pelvises of women who had previously undergone salpingectomies or tubal sterilization. While endosalpingiosis can have a similar appearance to endometriosis, usually yellow-white punctate cystic lesions, it differs in that there is no endometrial stroma noted. However, the pathogenesis of both diseases are similar in that they results from műllerianosis, where either multipotent peritoneal mesothelium undergoes metaplasia into oviduct epithelium or developed műllerian tissue is ectopically displaced.


How is this condition diagnosed?

While most cases of Endosalpingiosis have been discovered during incidental operative procedures, florid cystic endosalpingiosis usually presents clinically with pelvic pain, a mass noted on physical examination, or multiple cystic tumors seen on imaging. 

Is this condition related to Endometriosis?

Yes. While Endosalpingiosis is histologically differentiated from Endometriosis as Endosalpingiosis lacks endometrial stroma, Endometriosis is a similar, often painful disorder, in which tissue similar to the tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus. While they are two different types of conditions, both Endosalpingiosis and Endometriosis most commonly involves the ovaries, fallopian tubes and the tissue lining the pelvis.


What is the impact of having Endosalpingiosis?

The main potential outcomes of Endosalpingiosis is infertility, chronic pelvic pain, ovarian cancer and uterine cancer. However, several women report dysmenorrhea, excessive bleeding, fatigue, diarrhea, constipation, bloating or nausea, and anxiety in the form of irritability, especially during menstrual periods.

Society for Women Health

Endometriosis Toolkit: A Patient Empowerment Guide

SWHR’s toolkit is designed to empower individuals with endometriosis in navigating their care. The toolkit provides easy-to-understand information on menstrual health, guidance on endometriosis diagnosis and treatment, and tips for interacting with your health care provider.


Your mental health is important. There is no easy test that can let you know if certain thoughts, feelings and/or behaviors are the direct result of a serious mental health issue or a temporary (totally normal) reaction to a debilitating physical condition. Sometimes, debilitating physical conditions can result in a person developing a mental health condition.

Everyone is different, but it can help to know the common signs of a mental health condition in adults and adolescents, so that you can either get the help needed for your loved one or for yourself. If you or your loved one have any of the following signs, be sure you reach out for help. You are not alone. 

  • Excessive worrying or fear

  • Feeling excessively sad or low

  • Confused thinking or problems concentrating and learning

  • Extreme mood changes, including uncontrollable “highs” or feelings of euphoria

  • Prolonged or strong feelings of irritability or anger

  • Avoiding friends and social activities

  • Difficulties understanding or relating to other people

  • Changes in sleeping habits or feeling tired and low energy

  • Changes in eating habits such as increased hunger or lack of appetite

  • Changes in sex drive

  • Difficulty perceiving reality (delusions or hallucinations, in which a person experiences and senses things that don't exist in objective reality)

  • Inability to perceive changes in one’s own feelings, behavior or personality (”lack of insight” or anosognosia)

  • Overuse of substances like alcohol or drugs

  • Multiple physical ailments without obvious causes (such as headaches, stomach aches, vague and ongoing “aches and pains”)

  • Thinking about suicide

  • Inability to carry out daily activities or handle daily problems and stress

  • An intense fear of weight gain or concern with appearance

  • Mental health conditions can also begin to develop in young children. Because they’re still learning how to identify and talk about thoughts and emotions, their most obvious symptoms are behavioral. Symptoms in children may include the following:

  • Changes in school performance

  • Excessive worry or anxiety, for instance fighting to avoid bed or school

  • Hyperactive behavior

  • Frequent nightmares

  • Frequent disobedience or aggression

  • Frequent temper tantrums


Where To Get Help

Don’t be afraid to reach out if you or someone you know needs help. Learning and recognizing the signs of a mental health condition is an important first step. 


Contact the NAMI HelpLine to find out what services and supports are available in your community. 

If you or someone you know needs help, you should immediately call the National Suicide Prevention Lifeline at 1-800-273-8255 or call 911.