What is Endosalpingiosis?

Endosalpingiosis is a rare gynecological condition, which can affect females in reproductive age and postmenopausal women.  Abdominal pain is a commonly reported symptom of Endosalpingiosis. Characterized by the presence of tubal epithelium outside the fallopian tube, it can affect any organ in the abdomen and pelvis. High associations of Endosalpingiosis are found with ovarian cancer, endometriosis, and uterine cancer.


What is Endosalpingiosis?

Endosalpingiosis is the abnormal presence of endometrial glands and stroma in areas outside of the uterine. This rare condition mostly occurs in the pelvis but can be found throughout different body sites. Urinary tract endometriosis refers to the presence of this condition in the urethra, bladder, ureters or kidneys. Mullerianosis is a term that describes the presence of the endocervix, endosalpinx and/or endometrial tissues growing in the wrong location of the pelvic area.

For those that want a little more clinical detail ...

This rare condition is characterized by the presence of ectopic, cystic glands lined with ciliated epithelium similar to that found in the fallopian tube. It is most commonly found on pelvic organs such as the uterine serosa, fallopian tube serosa, ovaries, round ligament, and bladder, but has been documented in many other abdominal peritoneal and subperitoneal surfaces, including in retroperitoneal lymph nodes. It was first described by Sampson in 1930 when epithelium resembling the fallopian tube was noted in the pelvises of women who had previously undergone salpingectomies or tubal sterilization. While endosalpingiosis can have a similar appearance to endometriosis, usually yellow-white punctate cystic lesions, it differs in that there is no endometrial stroma noted. However, the pathogenesis of both diseases are similar in that they results from műllerianosis, where either multipotent peritoneal mesothelium undergoes metaplasia into oviduct epithelium or developed műllerian tissue is ectopically displaced.


How is this condition diagnosed?

While most cases of Endosalpingiosis have been discovered during incidental operative procedures, florid cystic endosalpingiosis usually presents clinically with pelvic pain, a mass noted on physical examination, or multiple cystic tumors seen on imaging. 

Is this condition related to Endometriosis?

Yes. While Endosalpingiosis is histologically differentiated from Endometriosis as Endosalpingiosis lacks endometrial stroma, Endometriosis is a similar, often painful disorder, in which tissue similar to the tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus. While they are two different types of conditions, both Endosalpingiosis and Endometriosis most commonly involves the ovaries, fallopian tubes and the tissue lining the pelvis.


What is the impact of having Endosalpingiosis?

The main potential outcomes of Endosalpingiosis is infertility, chronic pelvic pain, ovarian cancer and uterine cancer. However, several women report dysmenorrhea, excessive bleeding, fatigue, diarrhea, constipation, bloating or nausea, and anxiety in the form of irritability, especially during menstrual periods.